Velpanat®

Velpatasvir + Sofosbuvir

What is Velpanat and how does it work?

Velpanat is a medication used to treat chronic hepatitis C virus (HCV) infection in adults. It contains a combination of two active ingredients, Sofosbuvir and Velpatasvir, which work together to stop the virus from multiplying and spreading in the body. Sofosbuvir is a nucleotide analogue inhibitor that blocks the HCV RNA polymerase enzyme, while Velpatasvir is an NS5A inhibitor that prevents viral replication and assembly.

How is Velpanat taken?

Velpanat is taken orally, usually once a day, with or without food. The recommended dose is one tablet (400 mg sofosbuvir/100 mg velpatasvir) per day for 12 weeks. The duration of treatment may vary depending on the patient's genotype, liver function, and previous treatment history.

What are the side effects of Velpanat?

The most common side effects of Velpanat include headache, fatigue, nausea, diarrhea, and insomnia. Other less common side effects may include rash, itching, dizziness, and abdominal pain. Serious side effects such as liver failure or severe allergic reactions are rare but can occur.

Who should not take Velpanat?

Velpanat is not recommended for patients with severe liver impairment (Child-Pugh Class C) or those who have had a previous allergic reaction to any of its components. It should also not be taken with certain medications such as rifampin, carbamazepine, or St. John's wort, as they may reduce the effectiveness of Velpanat.

Is Velpanat effective in treating all genotypes of HCV?

Velpanat has been shown to be highly effective in treating all six genotypes of HCV, with cure rates ranging from 95% to 99%. However, the duration of treatment and the need for additional medications may vary depending on the patient's genotype and treatment history.

How long does it take for Velpanat to start working?

Velpanat can start working within a few days of starting treatment, but it may take several weeks before the virus is completely eliminated from the body. Patients are usually monitored closely during treatment to ensure that the medication is working effectively.

Can Velpanat be taken during pregnancy?

Velpanat is not recommended for use during pregnancy, as its safety and effectiveness have not been established in pregnant women. Women of childbearing age should use effective contraception during treatment and for several months after completing treatment.

Does Velpanat interact with other medications?

Velpanat may interact with certain medications such as rifampin, carbamazepine, or St. John's wort, which can reduce the effectiveness of Velpanat. Patients should inform their doctor of all medications they are taking, including over-the-counter medications and herbal supplements, before starting treatment with Velpanat.

How much does Velpanat cost in the UK?

The cost of Velpanat varies depending on the supplier and the quantity purchased. In the UK, the cost of a 28-day supply of Velpanat ranges from £6,500 to £8,000. However, the medication is available on the NHS for eligible patients.

How can I get Velpanat in the UK?

Velpanat is a prescription medication that can be obtained from a doctor or specialist who is experienced in treating hepatitis C. Patients may also be able to obtain Velpanat through the NHS if they meet certain eligibility criteria, such as having a certain level of liver damage or having failed previous treatments.